Scientists have succeeded in developing an effective method to treat the often lethal airway infections with nanoparticles that transport the antibiotics more efficiently to their destination.
Mucoviscidosis, also known as cystic fibrosis, is an inherited life-threatening disorder that damages the lungs and digestive system.
The lung is so significantly damaged that patients often die or need to have a lung transplant. Permanent treatment with inhaled antibiotics play a considerable part in this. While, the treatment can not avoid the colonisation by bacteria completely but it can keep it in check for a longer period of time.
The bacteria defends themselves with a development of resistance, but with the growth of so-called biofilms underneath the layer of mucus, which mostly block off the bacteria in the lower rows like a protective shield. To overcome the strong defense, the researchers encapsulated the active agents, like the antibiotic Tobramycin, in a polyester polymer.
The scientists discovered that their nanoparticle travels more easily through the sponge-like net of the mucus layer and is finally able to kill off the pathogens without any problems.
