Childhood trauma linked to increased risk of pregnancy complications

According to a pooled data analysis of the available evidence published in the open access journal BMJ Open, childhood trauma, such as abuse, emotional neglect, and exposure to domestic violence, may increase a woman's subsequent risk of pregnancy complications, as well as giving birth to a low birth weight or premature baby. The risks of pregnancy-related diabetes, high blood pressure, depression/anxiety and of giving birth to underweight and or premature babies may all be significantly higher, the analysis suggests.
While previously published research suggests that early life trauma can have a major negative impact on health in adulthood, it’s not clear if this extends to pregnancy. To explore this further, the researchers reviewed 32 relevant studies published between 1994 and 2022. Three out of 4 were long-term (cohort) studies, with the remainder observational or comparative (case-control) studies.
Most (19) were carried out in the USA. The rest were from Canada (3), Europe (6), and other regions (4). Study participants ranged in number from 48 to 11,556. Pooled data analysis of 21 studies showed that, overall, women who had experienced some form of childhood trauma were 37 per cent more likely to have pregnancy complications than those who hadn’t. They were also 31% more likely to give birth to underweight or premature babies.
Further in-depth analysis showed that childhood trauma was associated with a 39 per cent heightened risk of pregnancy-related diabetes, a 59 per cent heightened risk of antenatal depression, a 27 per cent heightened risk of giving birth to an underweight baby, and a 41 per cent heightened risk of preterm delivery. There could be several direct and indirect explanations for the findings, suggest the researchers. Childhood trauma might alter the regulation of stress signalling pathways and immune system function; it might also change brain structure and function, or it might speed up cellular ageing, they say.